The article I chose to share with my site evaluator was about morphine’s effect on anti-platelet drugs. I chose this article because it’s a topic I have been researching over the last few weeks and was also something I’m interested in after spending a week in the cardiothoracic unit.

This was a meta-analysis of randomized-controlled trials that included 69,993 participants. All participants had a history of ACS with STEMI or NSTEMI, and the outcomes investigated included in-hospital mortality, major adverse cardiovascular events, platelet reactivity, and bleeding. The effects of morphine were evaluated against placebo, control, and any other analgesic non-opioid drug.

The results showed an increased risk of in-hospital mortality, major adverse cardiovascular events and increased platelet reactivity at 1 and 2 hours associated with morphine. There was no significant difference in the risk of bleeding.

 

https://www.ncbi.nlm.nih.gov/pubmed/30878985